Neuroleptiques : Thyroxine (T4)

Invité

http://www.neuroleptic-awareness.co.uk/?Story_of_the_Brain

Citation:

Thryotropin Releasing Factor (TRF)
This releasing factor stimulates the pituitary gland to produce Thyroid Stimulating Hormone (TSH),which travels to the thyroid gland. Here thyroxine (T4) and calcitonin hormones are released.

Rinieris et al (1980) reports clozapine patients have decreased T4 and Baumgartner (2000) reports that neuroleptics suppress the release of TRH which follows through to the thyroid gland causing deficiencies of thyroxine and calcitonin hormones.

a) Thryroxine deficiency

T4 is concerned with the body's metabolic rate, the rate of the heart and blood pressure, healthy functioning nervous system and body temperature regulation.

Thyroxine is necessary for life - without thyroxine - people die.

Thyroxine deficiency is associated with premature aging - people who take neuroleptics long term will look more aged than their parents. Thyroxine deficiency causes a lowered basal metabolic rate (BMR) or lowered energy output, and is associated with weight gain and effects an increase in blood lipids and cholesterol.

Baumgartner (2000) :

Citation:

There was a significant fall in serum concentrations of T4 and rT3 during four weeks of drug treatment and the decrease was significantly correlated to clinical response.

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